Potassium Cation → 5-Difluoromethoxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

HRID 935900Notes

Reaction equation

HRID 935900 reaction equation
[C:18](=[O:19])([O-:20])[O-:21].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([OH:17])[cH:14][c:15]2[CH2:16]1.[Cl:24][C:25]([C:26]([O:27][CH2:28][CH3:29])=[O:30])([F:31])[F:32].[K+:22].[K+:23].[O:33]=[CH:34][N:35]([CH3:36])[CH3:37]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([O:17][CH:25]([F:31])[F:32])[cH:14][c:15]2[CH2:16]1

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 67843Acetic acid, 2-chloro-2,2-difluoro-, ethyl esterHCID 18630963tert-butyl 5-hydroxy-2,3-dihydro-1H-isoindole-2-carboxylate

Product 1

HCID 577532125-Difluoromethoxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-f4f5e34ef0224b64bc0b796296cacf3a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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