Potassium Cation → 2-(4-Bromo-2-methyl-phenyl)-8-oxa-2-aza-spiro[4.5]decan-1-one

HRID 935901Notes

Reaction equation

HRID 935901 reaction equation
[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH3:1][O:2][C:3](=[O:4])[C:5]1([CH2:11][CH2:12][NH:13][c:14]2[c:15]([CH3:21])[cH:16][c:17]([Br:20])[cH:18][cH:19]2)[CH2:6][CH2:7][O:8][CH2:9][CH2:10]1.[CH3:22][C:23]([CH3:24])([O-:25])[CH3:26].[Cl:35][CH2:36][Cl:37].[K+:27].[OH2:28].[Sn:29]>>[O:2]=[C:3]1[C:5]2([CH2:6][CH2:7][O:8][CH2:9][CH2:10]2)[CH2:11][CH2:12][N:13]1[c:14]1[c:15]([CH3:21])[cH:16][c:17]([Br:20])[cH:18][cH:19]1

Participants

8

Reactant 7

HCID 813Potassium CationHCID 962WaterHCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 45749132-Methylpropan-2-olateHCID 5352426Tin atomHCID 674223094-[2-(4-Bromo-2-methyl-phenylamino)-ethyl]-tetrahydro-pyran-4-carboxylic acid methyl ester

Product 1

HCID 584680462-(4-Bromo-2-methyl-phenyl)-8-oxa-2-aza-spiro[4.5]decan-1-one

Sources & evidence

ORD record
ord-394952b28d37423da9b7fc199b1964cf
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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