Isobutyryl chloride → 2-Methyl-1-[3-[[3-[5-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-b]pyrazin-2-yl]-2-pyridinyl]amino]pyrrolidin-1-yl]propan-1-one
Reaction equation
[C:30]([CH:31]([CH3:32])[CH3:33])(=[O:34])[Cl:35].[NH:1]1[CH2:2][CH:3]([NH:6][c:7]2[n:8][cH:9][cH:10][cH:11][c:12]2-[c:13]2[n:14][c:15]3[c:16]([n:17][cH:18]2)[n:19]([CH2:22][O:23][CH2:24][CH2:25][Si:26]([CH3:27])([CH3:28])[CH3:29])[cH:20][cH:21]3)[CH2:4][CH2:5]1>>[N:1]1([C:30]([CH:31]([CH3:32])[CH3:33])=[O:34])[CH2:2][CH:3]([NH:6][c:7]2[n:8][cH:9][cH:10][cH:11][c:12]2-[c:13]2[n:14][c:15]3[c:16]([n:17][cH:18]2)[n:19]([CH2:22][O:23][CH2:24][CH2:25][Si:26]([CH3:27])([CH3:28])[CH3:29])[cH:20][cH:21]3)[CH2:4][CH2:5]1Participants
3
Sources & evidence
- ORD record
- ord-f2abe73f1c164c8f90de2b1bce97ab15
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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