Hydrochloric Acid → N-cyclopropyl-5-fluoro-4'-(hydrazinocarbonyl)-6-methyl-1,1'-biphenyl-3-carboxamide

HRID 936330Notes

Reaction equation

[CH3:32][OH:33].[CH:1]1([NH:4][C:5](=[O:6])[c:7]2[cH:8][c:9]([F:31])[c:10]([CH3:30])[c:11](-[c:13]3[cH:14][cH:15][c:16]([C:19](=[O:20])[NH:21][NH:22][C:23]([O:24][C:25]([CH3:26])([CH3:27])[CH3:28])=[O:29])[cH:17][cH:18]3)[cH:12]2)[CH2:2][CH2:3]1.[ClH:34]>>[CH:1]1([NH:4][C:5](=[O:6])[c:7]2[cH:8][c:9]([F:31])[c:10]([CH3:30])[c:11](-[c:13]3[cH:14][cH:15][c:16]([C:19](=[O:20])[NH:21][NH2:22])[cH:17][cH:18]3)[cH:12]2)[CH2:2][CH2:3]1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 69316615Tert-butyl 2-({5'-[(cyclopropylamino)carbonyl]-3'-fluoro-2'-methyl-1,1'-biphenyl-4-yl}carbonyl)hydrazinecarboxylate

Product 1

HCID 69318167N-cyclopropyl-5-fluoro-4'-(hydrazinocarbonyl)-6-methyl-1,1'-biphenyl-3-carboxamide

Sources & evidence

ORD record: ord-c0b8d307ed9947678f92bacfe0267b19
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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