Dichloromethane → 1-(4-Cyanobenzenesulphonyl)-4-[1-(4-pyrimidinyl)piperidin-4-ylcarbonyl]piperazine

HRID 936351Notes

Reaction equation

HRID 936351 reaction equation
[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6]([S:9](=[O:10])(=[O:11])[Cl:12])[cH:7][cH:8]1.[CH3:33][CH2:34][N:35]([CH2:36][CH3:37])[CH2:38][CH3:39].[Cl:40][CH2:41][Cl:42].[n:13]1[cH:14][n:15][c:16]([N:19]2[CH2:20][CH2:21][CH:22]([C:25](=[O:26])[N:27]3[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]3)[CH2:23][CH2:24]2)[cH:17][cH:18]1>>[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6]([S:9](=[O:10])(=[O:11])[N:30]2[CH2:29][CH2:28][N:27]([C:25]([CH:22]3[CH2:21][CH2:20][N:19]([c:16]4[n:15][cH:14][n:13][cH:18][cH:17]4)[CH2:24][CH2:23]3)=[O:26])[CH2:32][CH2:31]2)[cH:7][cH:8]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 394974-Cyanobenzenesulfonyl chlorideHCID 186979701-[1-(4-Pyrimidinyl)-4-piperidylcarbonyl]piperazine

Product 1

HCID 186980611-(4-Cyanobenzenesulphonyl)-4-[1-(4-pyrimidinyl)piperidin-4-ylcarbonyl]piperazine

Sources & evidence

ORD record
ord-10d1fe0f1237451cbe1ac2e899e1ad6a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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