Piperidin-4-ol → 1-(benzo[d][1,3]dioxol-5-yl)-N-(5-((4-hydroxypiperidin-1-yl)(2-methoxyphenyl)methyl)pyridin-2-yl)cyclopropanecarboxamide

HRID 936355Notes

Reaction equation

HRID 936355 reaction equation
[CH3:1][S:2]([O:3][CH:6]([c:7]1[c:8]([O:13][CH3:14])[cH:9][cH:10][cH:11][cH:12]1)[c:15]1[cH:16][n:17][c:18]([NH:21][C:22](=[O:23])[C:24]2([c:27]3[cH:28][c:29]4[c:30]([cH:34][cH:35]3)[O:31][CH2:32][O:33]4)[CH2:25][CH2:26]2)[cH:19][cH:20]1)(=[O:4])=[O:5].[O:43]1[c:44]2[cH:45][cH:46][c:47]([C:48]3([C:49]([NH:50][c:51]4[cH:52][cH:53][c:54]([CH:55]([N:56]([CH3:57])[CH3:58])[c:59]5[cH:60][cH:61][cH:62][cH:63][c:64]5[O:65][CH3:66])[cH:67][n:68]4)=[O:69])[CH2:70][CH2:71]3)[cH:72][c:73]2[O:74][CH2:75]1.[OH:36][CH:37]1[CH2:38][CH2:39][NH:40][CH2:41][CH2:42]1>>[CH:6]([c:7]1[c:8]([O:13][CH3:14])[cH:9][cH:10][cH:11][cH:12]1)([c:15]1[cH:16][n:17][c:18]([NH:21][C:22](=[O:23])[C:24]2([c:27]3[cH:28][c:29]4[c:30]([cH:34][cH:35]3)[O:31][CH2:32][O:33]4)[CH2:25][CH2:26]2)[cH:19][cH:20]1)[N:40]1[CH2:39][CH2:38][CH:37]([OH:36])[CH2:42][CH2:41]1

Participants

4

Reactant 3

HCID 79341Piperidin-4-olHCID 442364971-(benzo[d][1,3]dioxol-5-yl)-N-(5-((dimethylamino)(2-methoxyphenyl)methyl)pyridin-2-yl)cyclopropanecarboxamideHCID 57895126(6-(1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)pyridin-3-yl)(2-methoxyphenyl)methyl methanesulfonate

Product 1

HCID 578951471-(benzo[d][1,3]dioxol-5-yl)-N-(5-((4-hydroxypiperidin-1-yl)(2-methoxyphenyl)methyl)pyridin-2-yl)cyclopropanecarboxamide

Sources & evidence

ORD record
ord-8084d65ab0ba4903ae8d0bcdfa2f6730
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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