Bromide ion → 3-benzyl-2-(1-hydroxy-2-methylprop-2-enyl)-4H-pyrido[1,2-a]pyrimidin-4-one

HRID 936552Notes

Reaction equation

HRID 936552 reaction equation
[Br-:21].[C:22](=[CH2:23])([CH3:24])[Mg+:25].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[c:9]([CH:19]=[O:20])[n:10][c:11]2[n:12]([c:13]1=[O:14])[cH:15][cH:16][cH:17][cH:18]2.[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[c:9]([CH:19]([OH:20])[C:22](=[CH2:23])[CH3:24])[n:10][c:11]2[n:12]([c:13]1=[O:14])[cH:15][cH:16][cH:17][cH:18]2

Participants

5

Reactant 4

HCID 259Bromide ionHCID 8028TetrahydrofuranHCID 596541753-benzyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carbaldehydeHCID 178456136HCID 178456136, compound

Product 1

HCID 575932043-benzyl-2-(1-hydroxy-2-methylprop-2-enyl)-4H-pyrido[1,2-a]pyrimidin-4-one

Sources & evidence

ORD record
ord-cb9f1d2edc0e452ba4d1b749a81298df
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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