Dichloromethane → Trifluoroacetic acid

HRID 936627Notes

Reaction equation

HRID 936627 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH:9]([CH2:13][NH:14][c:15]2[n:16][c:17]3[n:18]([c:19]([NH2:21])[n:20]2)[n:22][c:23](-[c:25]2[o:26][cH:27][cH:28][cH:29]2)[n:24]3)[CH2:10][CH2:11][CH2:12]1)([CH3:5])([CH3:6])[CH3:7].[Cl:37][CH2:38][Cl:39].[F:30][C:31]([C:32](=[O:33])[OH:34])([F:35])[F:36]>>[F:30][C:31]([C:32](=[O:33])[OH:34])([F:35])[F:36].[NH:8]1[CH:9]([CH2:13][NH:14][c:15]2[n:16][c:17]3[n:18]([c:19]([NH2:21])[n:20]2)[n:22][c:23](-[c:25]2[o:26][cH:27][cH:28][cH:29]2)[n:24]3)[CH2:10][CH2:11][CH2:12]1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 694333622-[(7-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Product 2

HCID 6422Trifluoroacetic acidHCID 694317402-furan-2-yl-N5-pyrrolidin-2-ylmethyl-[1,2,4]-triazolo[1,5-a][1,3,5]triazine-5,7-diamine

Sources & evidence

ORD record
ord-7143cba426324b538a7e3bd9f74cf872
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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