Acetic Acid → 3-Hydroxy-5-methyl-4-oxo-2-[(1,2,3,4-tetrahydro-isoquinolin-2-yl)carbonyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine

HRID 936651Notes

Reaction equation

HRID 936651 reaction equation
[BrH:32].[C:33]([OH:34])(=[O:35])[CH3:36].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10]([C:20](=[O:21])[N:22]2[CH2:23][c:24]3[cH:25][cH:26][cH:27][cH:28][c:29]3[CH2:30][CH2:31]2)[n:11][n:12]2[c:13]1[C:14](=[O:19])[N:15]([CH3:18])[CH2:16][CH2:17]2>>[OH:8][c:9]1[c:10]([C:20](=[O:21])[N:22]2[CH2:23][c:24]3[cH:25][cH:26][cH:27][cH:28][c:29]3[CH2:30][CH2:31]2)[n:11][n:12]2[c:13]1[C:14](=[O:19])[N:15]([CH3:18])[CH2:16][CH2:17]2

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 689539593-Benzyloxy-5-methyl-4-oxo-2-[(1,2,3,4-tetrahydro-isoquinolin-2-yl)carbonyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine

Product 1

HCID 547246423-Hydroxy-5-methyl-4-oxo-2-[(1,2,3,4-tetrahydro-isoquinolin-2-yl)carbonyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine

Sources & evidence

ORD record
ord-f82c1978012447c1a7656e03c21b2935
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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