Methanol → 2-Chloro-6-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl]-5-phenylnicotinonitrile

HRID 936911Notes

Reaction equation

HRID 936911 reaction equation
[Br:1][CH2:2][c:3]1[cH:4][cH:5][c:6](-[c:9]2[n:10][c:11]([Cl:23])[c:12]([C:13]#[N:14])[cH:15][c:16]2-[c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[cH:7][cH:8]1.[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:40][OH:41].[O:24]=[c:25]1[nH:26][c:27]2[c:28]([n:29]1[CH:30]1[CH2:31][CH2:32][NH:33][CH2:34][CH2:35]1)[cH:36][cH:37][cH:38][cH:39]2>>[CH2:2]([c:3]1[cH:4][cH:5][c:6](-[c:9]2[n:10][c:11]([Cl:23])[c:12]([C:13]#[N:14])[cH:15][c:16]2-[c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[cH:7][cH:8]1)[N:33]1[CH2:32][CH2:31][CH:30]([n:29]2[c:25](=[O:24])[nH:26][c:27]3[c:28]2[cH:36][cH:37][cH:38][cH:39]3)[CH2:35][CH2:34]1

Participants

5

Reactant 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 886381,3-Dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-oneHCID 866076536-[4-(Bromomethyl)phenyl]-2-chloro-5-phenylnicotinonitrile

Product 1

HCID 114098042-Chloro-6-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl]-5-phenylnicotinonitrile

Sources & evidence

ORD record
ord-32c00e366e5649bb9e2fe22d2bfa0d8e
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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