Potassium Cation → 3-[3-(4-Benzyloxyphenyl)-[1,2,4]thiadiazol-5-ylmethoxy]-2,6-difluorobenzamide

HRID 936920Notes

Reaction equation

HRID 936920 reaction equation
[C:34](=[O:35])([O-:36])[O-:37].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12](-[c:15]2[n:16][s:17][c:18]([CH2:20][Br:21])[n:19]2)[cH:13][cH:14]1.[F:22][c:23]1[c:24]([C:25](=[O:26])[NH2:27])[c:28]([F:33])[cH:29][cH:30][c:31]1[OH:32].[K+:38].[K+:39].[O:40]=[CH:41][N:42]([CH3:43])[CH3:44]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12](-[c:15]2[n:16][s:17][c:18]([CH2:20][O:32][c:31]3[c:23]([F:22])[c:24]([C:25](=[O:26])[NH2:27])[c:28]([F:33])[cH:29][cH:30]3)[n:19]2)[cH:13][cH:14]1

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 451201362,6-Difluoro-3-hydroxybenzamideHCID 595495273-(4-Benzyloxyphenyl)-5-bromomethyl-[1,2,4]thiadiazole

Product 1

HCID 595495343-[3-(4-Benzyloxyphenyl)-[1,2,4]thiadiazol-5-ylmethoxy]-2,6-difluorobenzamide

Sources & evidence

ORD record
ord-0a7785a3f0dd4330aff71a6bd86a9c4b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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