Phosgene → rac-(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride

HRID 937069Notes

Reaction equation

[CH3:39][CH2:40][N:41]([CH2:42][CH3:43])[CH2:44][CH3:45].[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([CH3:34])[N:9]=[C:10]([c:21]3[c:22]([O:31][CH2:32][CH3:33])[cH:23][c:24]([C:27]([F:28])([F:29])[F:30])[cH:25][cH:26]3)[NH:11][C:12]2([CH3:13])[c:14]2[cH:15][cH:16][c:17]([Cl:20])[cH:18][cH:19]2)[cH:6][cH:7]1.[Cl:35][C:36]([Cl:37])=[O:38]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([CH3:34])[N:9]=[C:10]([c:21]3[c:22]([O:31][CH2:32][CH3:33])[cH:23][c:24]([C:27]([F:28])([F:29])[F:30])[cH:25][cH:26]3)[N:11]([C:36]([Cl:35])=[O:38])[C:12]2([CH3:13])[c:14]2[cH:15][cH:16][c:17]([Cl:20])[cH:18][cH:19]2)[cH:6][cH:7]1

Participants

Reactant 3

HCID 6371Phosgene

HCID 8471Triethylamine

HCID 68685727rac-(4S*,5R*)-4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole

Product 1

HCID 73408688rac-(4S*,5R*)-4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride

Sources & evidence

ORD record: ord-e46256f818fa47ee885b8ec8543f61ee
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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