Water → Methyl 4-cyano-6-[[2-[(2-methylpropan-2-yl)oxycarbonylamino]cyclohexyl]amino]-2-(1-methylpyrazol-4-yl)pyridine-3-carboxylate

HRID 937113Notes

Reaction equation

HRID 937113 reaction equation
[CH3:36][CH2:37][O:38][C:39]([CH3:40])=[O:41].[Cl:1][c:2]1[n:3][c:4](-[c:14]2[cH:15][n:16][n:17]([CH3:19])[cH:18]2)[c:5]([C:6](=[O:7])[O:8][CH3:9])[c:10]([C:12]#[N:13])[cH:11]1.[NH2:20][CH:21]1[CH:22]([NH:27][C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[CH2:23][CH2:24][CH2:25][CH2:26]1.[OH2:35]>>[c:2]1([NH:20][CH:21]2[CH:22]([NH:27][C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[CH2:23][CH2:24][CH2:25][CH2:26]2)[n:3][c:4](-[c:14]2[cH:15][n:16][n:17]([CH3:19])[cH:18]2)[c:5]([C:6](=[O:7])[O:8][CH3:9])[c:10]([C:12]#[N:13])[cH:11]1

Participants

5

Reactant 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 3268011tert-Butyl (2-aminocyclohexyl)carbamateHCID 58317582methyl 6-chloro-4-cyano-2-(1-methyl-1H-pyrazol-4-yl)nicotinate

Product 1

HCID 77252951Methyl 4-cyano-6-[[2-[(2-methylpropan-2-yl)oxycarbonylamino]cyclohexyl]amino]-2-(1-methylpyrazol-4-yl)pyridine-3-carboxylate

Sources & evidence

ORD record
ord-6514964ad3fb45febf1bb580631094c1
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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