Imidazole → [1-[3-(3-chloro-6-oxo-1(6H)-pyridazinyl)propyl]-4-piperidinyl]methyl 4-amino-5-chloro-2,3-dihydro-7-benzofurancarboxylate

HRID 937188Notes

Reaction equation

HRID 937188 reaction equation
[CH2:45]1[O:46][CH2:47][CH2:48][CH2:49]1.[Cl:6][c:7]1[cH:8][cH:9][c:10](=[O:24])[n:11]([CH2:13][CH2:14][CH2:15][N:16]2[CH2:17][CH2:18][CH:19]([CH2:22][OH:23])[CH2:20][CH2:21]2)[n:12]1.[H-:26].[NH2:27][c:28]1[c:29]([Cl:44])[cH:30][c:31]([C:37](=[O:38])[n:39]2[cH:40][cH:41][n:42][cH:43]2)[c:32]2[c:33]1[CH2:34][CH2:35][O:36]2.[Na+:25].[nH:1]1[cH:2][cH:3][n:4][cH:5]1>>[Cl:6][c:7]1[cH:8][cH:9][c:10](=[O:24])[n:11]([CH2:13][CH2:14][CH2:15][N:16]2[CH2:17][CH2:18][CH:19]([CH2:22][O:23][C:37]([c:31]3[cH:30][c:29]([Cl:44])[c:28]([NH2:27])[c:33]4[c:32]3[O:36][CH2:35][CH2:34]4)=[O:38])[CH2:20][CH2:21]2)[n:12]1

Participants

7

Reactant 6

HCID 795ImidazoleHCID 923Sodium ionHCID 8028TetrahydrofuranHCID 166653HydrideHCID 22662740(4-Amino-5-chloro-2,3-dihydrobenzofuran-7-yl)(1H-imidazol-1-yl)methanoneHCID 226627606-chloro-2-[3-[4-(hydroxymethyl)-1-piperidinyl]propyl]-3(2H)-pyridazinone

Product 1

HCID 22662763[1-[3-(3-chloro-6-oxo-1(6H)-pyridazinyl)propyl]-4-piperidinyl]methyl 4-amino-5-chloro-2,3-dihydro-7-benzofurancarboxylate

Sources & evidence

ORD record
ord-9616e16199a743bcaa29a5d07e13fefb
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…