Acetic Acid → 3-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]aniline

HRID 937316Notes

Reaction equation

HRID 937316 reaction equation
[C:42]([OH:43])(=[O:44])[CH3:45].[CH2:29]([SnH:30]([CH2:31][CH2:32][CH2:33][CH3:34])[CH2:35][CH2:36][CH2:37][CH3:38])[CH2:39][CH2:40][CH3:41].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:16]3[cH:17][c:18]([NH:22][C:23](=[O:24])[O:25][CH2:26][CH:27]=[CH2:28])[cH:19][cH:20][cH:21]3)[n:10][c:11]([CH:13]([CH3:14])[CH3:15])[s:12]2)[n:7]1.[Cl:46][CH2:47][Cl:48]>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:16]3[cH:17][c:18]([NH2:22])[cH:19][cH:20][cH:21]3)[n:10][c:11]([CH:13]([CH3:14])[CH3:15])[s:12]2)[n:7]1

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 5948TributylstannaneHCID 6344DichloromethaneHCID 57989663HCID 57989663, compound

Product 1

HCID 579900463-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]aniline

Sources & evidence

ORD record
ord-1baa7869ec4a4756a2a1850e167565ba
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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