Tetrahydrofuran → Ethyl 4-[[[[4-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-amino]thioxomethyl]amino]-1-piperidinecarboxylate

HRID 937433Notes

Reaction equation

HRID 937433 reaction equation
[F:15][c:16]1[cH:17][cH:18][c:19]([CH2:22][NH:23][c:24]2[c:25]([NH2:30])[cH:26][n:27][cH:28][cH:29]2)[cH:20][cH:21]1.[N:1](=[C:2]=[S:3])[CH:4]1[CH2:5][CH2:6][N:7]([C:10](=[O:11])[O:12][CH2:13][CH3:14])[CH2:8][CH2:9]1.[O:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1>>[NH:1]([C:2](=[S:3])[NH:30][c:25]1[c:24]([NH:23][CH2:22][c:19]2[cH:18][cH:17][c:16]([F:15])[cH:21][cH:20]2)[cH:29][cH:28][n:27][cH:26]1)[CH:4]1[CH2:5][CH2:6][N:7]([C:10](=[O:11])[O:12][CH2:13][CH3:14])[CH2:8][CH2:9]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 3018454Ethyl 4-isothiocyanatopiperidine-1-carboxylateHCID 13587968(3-Amino(4-pyridyl))[(4-fluorophenyl)methyl]amine

Product 1

HCID 13587974Ethyl 4-[[[[4-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-amino]thioxomethyl]amino]-1-piperidinecarboxylate

Sources & evidence

ORD record
ord-3574e6c3374c4cb3a57b58e8182b1d40
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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