Benzonitrile, 4-bromo- → 1-Boc-4-[(4-cyanophenyl)amino]-piperidine

HRID 937531Notes

Reaction equation

HRID 937531 reaction equation
[Br:15][c:16]1[cH:17][cH:18][c:19]([C:20]#[N:21])[cH:22][cH:23]1.[C:24]([c:25]1[cH:26][c:27]([NH:28][CH:29]2[CH2:30][CH2:31][N:32]([C:33]([O:34][C:35]([CH3:36])([CH3:37])[CH3:38])=[O:39])[CH2:40][CH2:41]2)[cH:42][cH:43][cH:44]1)#[N:45].[NH2:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1>>[NH:1]([CH:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1)[c:16]1[cH:17][cH:18][c:19]([C:20]#[N:21])[cH:22][cH:23]1

Participants

4

Reactant 3

HCID 12162Benzonitrile, 4-bromo-HCID 12682914-Amino-1-Boc-piperidineHCID 252237961,1-Dimethylethyl 4-[(3-cyanophenyl)amino]-1-piperidinecarboxylate

Product 1

HCID 185392071-Boc-4-[(4-cyanophenyl)amino]-piperidine

Sources & evidence

ORD record
ord-ef9a50cee1334a79a4bb794dc4769fbd
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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