Dichloromethane → 4-[4-Chloro-2-(2-piperazin-1-ylpyrimidin-4-yl)phenoxy]-3-cyano-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

HRID 937560Notes

Reaction equation

[CH2:52]([Cl:53])[Cl:54].[Cl:8][c:9]1[cH:10][cH:11][c:12]([O:34][c:35]2[c:36]([C:50]#[N:51])[cH:37][c:38]([S:41](=[O:42])(=[O:43])[NH:44][c:45]3[n:46][cH:47][n:48][s:49]3)[cH:39][cH:40]2)[c:13](-[c:15]2[n:16][c:17]([N:21]3[CH2:22][CH2:23][N:24]([C:27]([O:28][C:29]([CH3:30])([CH3:31])[CH3:32])=[O:33])[CH2:25][CH2:26]3)[n:18][cH:19][cH:20]2)[cH:14]1.[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[Cl:8][c:9]1[cH:10][cH:11][c:12]([O:34][c:35]2[c:36]([C:50]#[N:51])[cH:37][c:38]([S:41](=[O:42])(=[O:43])[NH:44][c:45]3[n:46][cH:47][n:48][s:49]3)[cH:39][cH:40]2)[c:13](-[c:15]2[n:16][c:17]([N:21]3[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]3)[n:18][cH:19][cH:20]2)[cH:14]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 66905486Tert-butyl 4-[4-(5-chloro-2-{2-cyano-4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]phenoxy}phenyl)pyrimidin-2-yl]piperazine-1-carboxylate

Product 1

HCID 468417904-[4-Chloro-2-(2-piperazin-1-ylpyrimidin-4-yl)phenoxy]-3-cyano-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

Sources & evidence

ORD record: ord-ca0c6c8da6b04a9fae339145f2171612
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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