Phosgene → rac-(4S,5R)-2-(4-Bromo-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride

HRID 937579Notes

Reaction equation

[Br:1][c:2]1[cH:3][c:4]([O:29][CH2:30][CH3:31])[c:5]([C:8]2=[N:12][C:11]([CH3:13])([c:14]3[cH:15][cH:16][c:17]([Cl:20])[cH:18][cH:19]3)[C:10]([CH3:21])([c:22]3[cH:23][cH:24][c:25]([Cl:28])[cH:26][cH:27]3)[NH:9]2)[cH:6][cH:7]1.[CH3:36][CH2:37][N:38]([CH2:39][CH3:40])[CH2:41][CH3:42].[Cl:32][C:33]([Cl:34])=[O:35]>>[Br:1][c:2]1[cH:3][c:4]([O:29][CH2:30][CH3:31])[c:5]([C:8]2=[N:9][C:10]([CH3:21])([c:22]3[cH:23][cH:24][c:25]([Cl:28])[cH:26][cH:27]3)[C:11]([CH3:13])([c:14]3[cH:15][cH:16][c:17]([Cl:20])[cH:18][cH:19]3)[N:12]2[C:33]([Cl:32])=[O:35])[cH:6][cH:7]1

Participants

Reactant 3

HCID 6371Phosgene

HCID 8471Triethylamine

HCID 68683683rac-(4S*,5R*)-2-(4-Bromo-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole

Product 1

HCID 73408748rac-(4S*,5R*)-2-(4-Bromo-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride

Sources & evidence

ORD record: ord-92fd6edb7fd54241b69ccf3d50582dfd
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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