Dichloromethane → 3-Amino-6-(2,3-difluorophenyl)-1-pyridin-4-ylazepan-2-one
Reaction equation
[Cl:38][CH2:39][Cl:40].[F:8][c:9]1[c:10]([CH:16]2[CH2:17][CH2:18][CH:19]([NH:30][C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[C:20](=[O:29])[N:21]([c:23]3[cH:24][cH:25][n:26][cH:27][cH:28]3)[CH2:22]2)[cH:11][cH:12][cH:13][c:14]1[F:15].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[F:8][c:9]1[c:10]([CH:16]2[CH2:17][CH2:18][CH:19]([NH2:30])[C:20](=[O:29])[N:21]([c:23]3[cH:24][cH:25][n:26][cH:27][cH:28]3)[CH2:22]2)[cH:11][cH:12][cH:13][c:14]1[F:15]Participants
4
Sources & evidence
- ORD record
- ord-6d36e87478fe4ed5b5d5888a187bdf31
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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