Toluene → N-(3-bromo-4-methyl-phenyl)4-(4-methyl-piperazin-1-ylmethyl)-benzamide

HRID 937768Notes

Reaction equation

HRID 937768 reaction equation
[Br:5][c:6]1[cH:7][c:8]([NH2:9])[cH:10][cH:11][c:12]1[CH3:13].[CH3:14][O:15][C:16]([c:17]1[cH:18][cH:19][c:20]([CH2:23][N:24]2[CH2:25][CH2:26][N:27]([CH3:30])[CH2:28][CH2:29]2)[cH:21][cH:22]1)=[O:31].[CH3:1][Al:2]([CH3:3])[CH3:4].[CH3:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1>>[Br:5][c:6]1[cH:7][c:8]([NH:9][C:16](=[O:15])[c:17]2[cH:18][cH:19][c:20]([CH2:23][N:24]3[CH2:25][CH2:26][N:27]([CH3:30])[CH2:28][CH2:29]3)[cH:21][cH:22]2)[cH:10][cH:11][c:12]1[CH3:13]

Participants

5

Reactant 4

HCID 1140TolueneHCID 82187Benzenamine, 3-bromo-4-methyl-HCID 782222Methyl 4-((4-methylpiperazin-1-yl)methyl)benzoateHCID 16682925Trimethylaluminum

Product 1

HCID 10309714N-(3-bromo-4-methyl-phenyl)4-(4-methyl-piperazin-1-ylmethyl)-benzamide

Sources & evidence

ORD record
ord-62e73f1b8b2045888e1e596072613747
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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