Tetrahydrofuran → 3-Amino-6-(4-fluoro-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid

HRID 937784Notes

Reaction equation

HRID 937784 reaction equation
[C:26](=[O:27])([O-:28])[O-:29].[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[Cs+:30].[Cs+:31].[NH2:1][c:2]1[c:3]([C:13](=[O:14])[OH:15])[n:4][c:5]([Br:12])[c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1.[OH:16][B:17]([OH:18])[c:19]1[cH:20][cH:21][c:22]([F:23])[cH:24][cH:25]1>>[NH2:1][c:2]1[c:3]([C:13](=[O:14])[OH:15])[n:4][c:5](-[c:19]2[cH:20][cH:21][c:22]([F:23])[cH:24][cH:25]2)[c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 2856454-Fluorophenylboronic acidHCID 584423503-Amino-6-bromo-5-(trifluoromethyl)picolinic acid

Product 1

HCID 584423103-Amino-6-(4-fluoro-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid

Sources & evidence

ORD record
ord-a199e1b3f4cd429b8b2acdca520a8b8f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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