Hydrochloric Acid → 4-{4-[2-(tert-Butyldimethylsilanyloxy)ethoxy]phenyl}piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester

HRID 938091Notes

Reaction equation

HRID 938091 reaction equation
[CH3:1][O:2][C:3](=[O:4])[C:5]1=[C:10]([c:11]2[cH:12][cH:13][c:14]([O:17][CH2:18][CH2:19][O:20][Si:21]([CH3:22])([CH3:23])[C:24]([CH3:25])([CH3:26])[CH3:27])[cH:15][cH:16]2)[CH2:9][CH2:8][N:7]([C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[CH2:6]1.[CH3:36][OH:37].[ClH:35]>>[CH3:1][O:2][C:3](=[O:4])[CH:5]1[CH2:6][N:7]([C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[CH2:8][CH2:9][CH:10]1[c:11]1[cH:12][cH:13][c:14]([O:17][CH2:18][CH2:19][O:20][Si:21]([CH3:22])([CH3:23])[C:24]([CH3:25])([CH3:26])[CH3:27])[cH:15][cH:16]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 684912491-(Tert-butyl) 3-methyl 4-(4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)-5,6-dihydropyridine-1,3(2h)-dicarboxylate

Product 1

HCID 684257344-{4-[2-(tert-Butyldimethylsilanyloxy)ethoxy]phenyl}piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester

Sources & evidence

ORD record
ord-65ed6c6822214ffb923a23be0e0f1261
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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