Dichloromethane → Trifluoroacetic acid

HRID 938094Notes

Reaction equation

HRID 938094 reaction equation
[CH3:1][O:2][c:3]1[c:4]([O:46][CH2:47][CH2:48][O:49][CH3:50])[cH:5][c:6]2[c:7]([NH:29][c:30]3[cH:31][c:32]4[cH:33][n:34][n:35]([C:39]([O:40][C:41]([CH3:42])([CH3:43])[CH3:44])=[O:45])[c:36]4[cH:37][cH:38]3)[n:8][c:9](-[c:13]3[cH:14][c:15]([NH:19][C:20]([CH2:21][N:22]4[CH2:23][CH2:24][O:25][CH2:26][CH2:27]4)=[O:28])[cH:16][cH:17][cH:18]3)[n:10][c:11]2[cH:12]1.[Cl:58][CH2:59][Cl:60].[F:51][C:52]([C:53](=[O:54])[OH:55])([F:56])[F:57]>>[CH3:1][O:2][c:3]1[c:4]([O:46][CH2:47][CH2:48][O:49][CH3:50])[cH:5][c:6]2[c:7]([NH:29][c:30]3[cH:31][c:32]4[cH:33][n:34][nH:35][c:36]4[cH:37][cH:38]3)[n:8][c:9](-[c:13]3[cH:14][c:15]([NH:19][C:20]([CH2:21][N:22]4[CH2:23][CH2:24][O:25][CH2:26][CH2:27]4)=[O:28])[cH:16][cH:17][cH:18]3)[n:10][c:11]2[cH:12]1.[F:51][C:52]([C:53](=[O:54])[OH:55])([F:56])[F:57]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59361918HCID 59361918, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 25012086N-[3-[4-(1H-indazol-5-ylamino)-7-methoxy-6-(2-methoxyethoxy)quinazolin-2-yl]phenyl]-2-morpholin-4-ylacetamide

Sources & evidence

ORD record
ord-db0bae672360417184cfb5ab46814a43
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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