Dichloromethane → 2-((1-tosyl-1H-indol-3-yl)methyl)-2,9-diazaspiro[5.5]undecan-1-one
Reaction equation
[Cl:47][CH2:48][Cl:49].[F:40][C:41]([F:42])([F:43])[C:44]([OH:45])=[O:46].[O:1]=[C:2]1[N:3]([CH2:20][c:21]2[cH:22][n:23]([S:30](=[O:31])(=[O:32])[c:33]3[cH:34][cH:35][c:36]([CH3:37])[cH:38][cH:39]3)[c:24]3[cH:25][cH:26][cH:27][cH:28][c:29]23)[CH2:4][CH2:5][CH2:6][C:7]12[CH2:8][CH2:9][N:10]([C:13]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[CH2:11][CH2:12]2>>[O:1]=[C:2]1[N:3]([CH2:20][c:21]2[cH:22][n:23]([S:30](=[O:31])(=[O:32])[c:33]3[cH:34][cH:35][c:36]([CH3:37])[cH:38][cH:39]3)[c:24]3[cH:25][cH:26][cH:27][cH:28][c:29]23)[CH2:4][CH2:5][CH2:6][C:7]12[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2Participants
4
Sources & evidence
- ORD record
- ord-6450b82ecad24ebb9703a38b92ace682
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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