Dimethyl Sulfoxide → Tert-butyl 4-(4-chlorophthalazin-1-yl)-3-methylpiperazine-1-carboxylate

HRID 938256Notes

Reaction equation

HRID 938256 reaction equation
[CH3:13][CH:14]1[CH2:15][N:16]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:17][CH2:18][NH:19]1.[CH3:27][CH2:28][N:29]([CH2:30][CH3:31])[CH2:32][CH3:33].[CH3:35][S:36]([CH3:37])=[O:38].[Cl:1][c:2]1[n:3][n:4][c:5]([Cl:12])[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12.[OH2:34]>>[c:2]1([N:19]2[CH:14]([CH3:13])[CH2:15][N:16]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:17][CH2:18]2)[n:3][n:4][c:5]([Cl:12])[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 8471TriethylamineHCID 784901,4-DichlorophthalazineHCID 2756810tert-Butyl 3-methylpiperazine-1-carboxylate

Product 1

HCID 76610677Tert-butyl 4-(4-chlorophthalazin-1-yl)-3-methylpiperazine-1-carboxylate

Sources & evidence

ORD record
ord-cc1fe69f67a24d3d80b2742d23a64919
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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