Potassium Cation → 3-(2-amino-6-quinazolinyl)-1-(3-chlorophenyl)-4-methyl-2(1H)-pyridinone

HRID 938367Notes

Reaction equation

HRID 938367 reaction equation
[CH3:36][NH:37][CH2:38][CH2:39][NH:40][CH3:41].[Cl:28][c:29]1[cH:30][c:31]([I:35])[cH:32][cH:33][cH:34]1.[Cu:42][I:43].[K+:25].[K+:26].[K+:27].[NH2:1][c:2]1[n:3][c:4]2[cH:5][cH:6][c:7](-[c:12]3[c:13](=[O:19])[nH:14][cH:15][cH:16][c:17]3[CH3:18])[cH:8][c:9]2[cH:10][n:11]1.[O:44]1[CH2:45][CH2:46][O:47][CH2:48][CH2:49]1.[P:20]([O-:21])([O-:22])([O-:23])=[O:24]>>[NH2:1][c:2]1[n:3][c:4]2[cH:5][cH:6][c:7](-[c:12]3[c:13](=[O:19])[n:14](-[c:31]4[cH:30][c:29]([Cl:28])[cH:34][cH:33][cH:32]4)[cH:15][cH:16][c:17]3[CH3:18])[cH:8][c:9]2[cH:10][n:11]1

Participants

8

Reactant 7

HCID 813Potassium Cation3×HCID 1061PhosphateHCID 8070N,N'-DimethylethylenediamineHCID 122691-Chloro-3-iodobenzeneHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 312751,4-DioxaneHCID 669999863-(2-aminoquinazolin-6-yl)-4-methylpyridin-2(1H)-one

Product 1

HCID 250687803-(2-amino-6-quinazolinyl)-1-(3-chlorophenyl)-4-methyl-2(1H)-pyridinone

Sources & evidence

ORD record
ord-598f0ff6ebc04c6a9cb555d8acd097e0
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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