Acetonitrile → Methyl 4-({1-[2-(4-cyanophenyl)ethyl]-4-hydroxypiperidin-4-ylmethyl}amino)benzoate

HRID 938383Notes

Reaction equation

HRID 938383 reaction equation
[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6]([CH2:9][CH2:10][N:11]2[CH2:12][CH2:13][C:14]3([O:15][CH2:16]3)[CH2:17][CH2:18]2)[cH:7][cH:8]1.[CH3:36][C:37]#[N:38].[Cl+3:30]([O-:31])([O-:32])([O-:33])[O-:34].[Li+:35].[NH2:19][c:20]1[cH:21][cH:22][c:23]([C:24](=[O:25])[O:26][CH3:27])[cH:28][cH:29]1>>[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6]([CH2:9][CH2:10][N:11]2[CH2:12][CH2:13][C:14]([OH:15])([CH2:16][NH:19][c:20]3[cH:21][cH:22][c:23]([C:24](=[O:25])[O:26][CH3:27])[cH:28][cH:29]3)[CH2:17][CH2:18]2)[cH:7][cH:8]1

Participants

6

Reactant 5

HCID 6342AcetonitrileHCID 12082Methyl 4-aminobenzoateHCID 28486Lithium ionHCID 123351PerchlorateHCID 858197211-[2-(4-Cyanophenyl)ethyl]piperidin-4-spiro-2'-oxirane

Product 1

HCID 22930224Methyl 4-({1-[2-(4-cyanophenyl)ethyl]-4-hydroxypiperidin-4-ylmethyl}amino)benzoate

Sources & evidence

ORD record
ord-49f5ff4dbd984297bc252b654faeceb8
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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