Water → 1-(tert-Butoxycarbonyl)-4-((p-toluenesulfonyloxy)methyl)piperidine

HRID 938398Notes

Reaction equation

HRID 938398 reaction equation
[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][OH:15])[CH2:12][CH2:13]1.[OH2:27].[S:16](=[O:17])(=[O:18])([c:19]1[cH:20][cH:21][c:22]([CH3:23])[cH:24][cH:25]1)[Cl:26].[cH:28]1[cH:29][cH:30][n:31][cH:32][cH:33]1>>[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][O:15][S:16](=[O:17])(=[O:18])[c:19]2[cH:20][cH:21][c:22]([CH3:23])[cH:24][cH:25]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 2764081Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate

Product 1

HCID 106428511-(tert-Butoxycarbonyl)-4-((p-toluenesulfonyloxy)methyl)piperidine

Sources & evidence

ORD record
ord-3a1cfd812de94771ae635c38cb1a7d9a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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