Dichloromethane → 4-(4-Chloro-2-fluoroanilino)6-methoxy-7-(2-(2-oxoimidazolidin-1-yl)ethoxy)quinazoline

HRID 938495Notes

Reaction equation

HRID 938495 reaction equation
[CH2:23]([P:24]([CH2:25][CH2:26][CH2:27][CH3:28])[CH2:29][CH2:30][CH2:31][CH3:32])[CH2:33][CH2:34][CH3:35].[CH2:45]([Cl:46])[Cl:47].[Cl:1][c:2]1[cH:3][c:4]([F:22])[c:5]([NH:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([OH:19])[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:20][cH:21]1.[OH:36][CH2:37][CH2:38][N:39]1[C:40](=[O:44])[NH:41][CH2:42][CH2:43]1>>[Cl:1][c:2]1[cH:3][c:4]([F:22])[c:5]([NH:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([O:19][CH2:37][CH2:38][N:39]4[C:40](=[O:44])[NH:41][CH2:42][CH2:43]4)[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:20][cH:21]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 13831TributylphosphineHCID 77290Hydroxyethyl imidazolidinoneHCID 1355137204-(4-Chloro-2-fluorophenylamino)-7-hydroxy-6-methoxyquinazoline

Product 1

HCID 187534334-(4-Chloro-2-fluoroanilino)6-methoxy-7-(2-(2-oxoimidazolidin-1-yl)ethoxy)quinazoline

Sources & evidence

ORD record
ord-05da70ca9b864321ba7899bd4e828d6b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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