Acetone → 2-[1-[3-(3-(3-Pyridyl)prop-2-yn-1-yloxy)phenyl]-1-methoxypropyl]thiazole

HRID 938742Notes

Reaction equation

HRID 938742 reaction equation
[BrH:24].[C:18](=[O:19])([O-:20])[O-:21].[CH3:35][C:36](=[O:37])[CH3:38].[K+:22].[K+:23].[OH:1][c:2]1[cH:3][c:4]([C:8]([CH2:9][CH3:10])([O:11][CH3:12])[c:13]2[s:14][cH:15][cH:16][n:17]2)[cH:5][cH:6][cH:7]1.[n:25]1[cH:26][c:27]([C:31]#[C:32][CH2:33][Br:34])[cH:28][cH:29][cH:30]1>>[O:1]([c:2]1[cH:3][c:4]([C:8]([CH2:9][CH3:10])([O:11][CH3:12])[c:13]2[s:14][cH:15][cH:16][n:17]2)[cH:5][cH:6][cH:7]1)[CH2:33][C:32]#[C:31][c:27]1[cH:26][n:25][cH:30][cH:29][cH:28]1

Participants

7

Reactant 6

HCID 180AcetoneHCID 260Hydrogen BromideHCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 156373793-[1-Methoxy-1-(1,3-thiazol-2-yl)propyl]phenolHCID 167329223-(3-Bromoprop-1-yn-1-yl)pyridine

Product 1

HCID 191016422-[1-[3-(3-(3-Pyridyl)prop-2-yn-1-yloxy)phenyl]-1-methoxypropyl]thiazole

Sources & evidence

ORD record
ord-fd228d32343c4089909d3a62f52b6f6b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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