Sodium ion → 2,3-difluoro-5-[3-(2-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N,N-dimethyl-benzamide

HRID 938769Notes

Reaction equation

HRID 938769 reaction equation
[CH3:1][O:2][c:3]1[c:4](-[c:9]2[n:10][n:11]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:32])([CH3:33])[CH3:34])[c:12]3[n:13][cH:14][c:15]([B:18]4[O:19][C:20]([CH3:21])([CH3:22])[C:23]([CH3:24])([CH3:25])[O:26]4)[cH:16][c:17]23)[cH:5][cH:6][cH:7][cH:8]1.[CH3:62][C:63]#[N:64].[F:35][c:36]1[c:37]([C:38](=[O:39])[N:40]([CH3:41])[CH3:42])[cH:43][c:44]([I:48])[cH:45][c:46]1[F:47].[Na+:49].[Na+:50].[Na+:55].[Na+:56].[O-:51][C:52](=[O:53])[O-:54].[O-:57][S:58](=[O:59])(=[O:60])[O-:61]>>[CH3:1][O:2][c:3]1[c:4](-[c:9]2[n:10][n:11]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:32])([CH3:33])[CH3:34])[c:12]3[n:13][cH:14][c:15](-[c:44]4[cH:43][c:37]([C:38](=[O:39])[N:40]([CH3:41])[CH3:42])[c:36]([F:35])[c:46]([F:47])[cH:45]4)[cH:16][c:17]23)[cH:5][cH:6][cH:7][cH:8]1

Participants

7

Reactant 6

HCID 923Sodium ion4×HCID 1117Sulfate IonHCID 6342AcetonitrileHCID 19660Carbonate IonHCID 579757722,3-difluoro-5-iodo-N,N-dimethyl-benzamideHCID 598360923-(2-methoxy-phenyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-(2-trimethylsilanyl-ethoxy-methyl)-1H-pyrazolo[3,4-b]pyridine

Product 1

HCID 579757282,3-difluoro-5-[3-(2-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N,N-dimethyl-benzamide

Sources & evidence

ORD record
ord-e00f7d125e284bbdafb1557729194659
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…