Trifluoroacetic acid → 2-[3-[[4-[[2-(2-Chloro-4-fluorophenyl)acetyl]-ethylamino]piperidin-1-yl]methyl]-4-phenylpyrrolidin-1-yl]-3-cyclobutylpropanoic acid

HRID 939491Notes

Reaction equation

HRID 939491 reaction equation
[C:23]([CH:24]([O:25][SiH:26]([CH3:27])[CH3:28])[CH:29]1[CH:30]([c:31]2[cH:32][cH:33][cH:34][cH:35][cH:36]2)[CH2:37][NH:38][CH2:39]1)([CH3:40])([CH3:41])[CH3:42].[CH:1](=[O:2])[CH:3]1[CH2:4][N:5]([CH:14]([C:15](=[O:16])[OH:17])[CH2:18][CH:19]2[CH2:20][CH2:21][CH2:22]2)[CH2:6][CH:7]1[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1.[Cl:50][c:51]1[c:52]([CH2:53][C:54](=[O:55])[N:56]([CH2:57][CH3:58])[CH:59]2[CH2:60][CH2:61][NH:62][CH2:63][CH2:64]2)[cH:65][cH:66][c:67]([F:69])[cH:68]1.[F:43][C:44]([F:45])([F:46])[C:47]([OH:48])=[O:49]>>[CH2:1]([CH:3]1[CH2:4][N:5]([CH:14]([C:15](=[O:16])[OH:17])[CH2:18][CH:19]2[CH2:20][CH2:21][CH2:22]2)[CH2:6][CH:7]1[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[N:62]1[CH2:61][CH2:60][CH:59]([N:56]([C:54]([CH2:53][c:52]2[c:51]([Cl:50])[cH:68][c:67]([F:69])[cH:66][cH:65]2)=[O:55])[CH2:57][CH3:58])[CH2:64][CH2:63]1

Participants

5

Reactant 4

HCID 6422Trifluoroacetic acidHCID 183747143-Cyclobutyl-2-(3-formyl-4-phenylpyrrolidin-1-yl)propanoic acidHCID 544239722-(2-chloro-4-fluorophenyl)-N-ethyl-N-piperidin-4-ylacetamideHCID 173255717[2,2-Dimethyl-1-(4-phenylpyrrolidin-3-yl)propoxy]-dimethylsilane

Product 1

HCID 224582432-[3-[[4-[[2-(2-Chloro-4-fluorophenyl)acetyl]-ethylamino]piperidin-1-yl]methyl]-4-phenylpyrrolidin-1-yl]-3-cyclobutylpropanoic acid

Sources & evidence

ORD record
ord-7714918e2a794bd2b09955a0d542dda9
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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