1,2-Dichloroethane → 5-(4-Chlorophenyl)-2-piperidin-4-ylpyrimidine

HRID 939538Notes

Reaction equation

HRID 939538 reaction equation
[CH3:28][OH:29].[CH3:34][CH2:35][O:36][CH2:37][CH3:38].[Cl:1][C:2]([O:3][CH:4]([Cl:5])[CH3:6])=[O:7].[Cl:30][CH2:31][CH2:32][Cl:33].[Cl:8][c:9]1[cH:10][cH:11][c:12](-[c:15]2[cH:16][n:17][c:18]([CH:21]3[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]3)[n:19][cH:20]2)[cH:13][cH:14]1>>[Cl:8][c:9]1[cH:10][cH:11][c:12](-[c:15]2[cH:16][n:17][c:18]([CH:21]3[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]3)[n:19][cH:20]2)[cH:13][cH:14]1

Participants

6

Reactant 5

HCID 111,2-DichloroethaneHCID 887MethanolHCID 3283Diethyl EtherHCID 5213051-Chloroethyl chloroformateHCID 226466965-(4-Chlorophenyl)-2-(1-methylpiperidin-4-yl)pyrimidine

Product 1

HCID 226466975-(4-Chlorophenyl)-2-piperidin-4-ylpyrimidine

Sources & evidence

ORD record
ord-b3527a8f57d5493ba6f19911ab769dfb
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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