反应详情

1-[3-(7-Bromo3-nitroquinolin-4-ylamino)propyl]pyrrolidin-2-one was treated according to the methods described in Parts B, C, and D of Examples 152–156. 3-Methoxypropionyl chloride was used in Part C, and triethylamine (1.3 equivalents) was added to the reaction mixture. The crude product obtained in Part D was purified by flash chromatography on silica gel (eluting sequentially with 100:0 and 92.5:7.5 chloroform:methanol) followed by recrystallization from acetonitrile. The crystals were washed with acetonitrile and diethyl ether and dried in a vacuum oven at 60° C. to provide 1-{3-[7-bromo-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}pyrrolidin-2-one as a light grey solid.

1. additionwas added to the reaction mixture
2. customThe crude product obtained in Part D
3. customwas purified by flash chromatography on silica gel (
4. washeluting sequentially with 100:0 and 92.5:7.5 chloroform
5. custommethanol) followed by recrystallization from acetonitrile
6. washThe crystals were washed with acetonitrile and diethyl ether
7. customdried in a vacuum oven at 60° C.