Diethyl Ether → 6-Chloro-5-methylnicotinic acid isopropyl ester
Reaction equation
[CH3:16][Si:17]([Cl:18])([CH3:19])[CH3:20].[CH3:21][CH2:22][O:23][CH2:24][CH3:25].[CH:12]([CH3:13])([CH3:14])[OH:15].[Cl:1][c:2]1[n:3][cH:4][c:5]([C:6](=[O:7])[OH:8])[cH:9][c:10]1[CH3:11]>>[Cl:1][c:2]1[n:3][cH:4][c:5]([C:6]([O:7][CH:12]([CH3:13])[CH3:14])=[O:8])[cH:9][c:10]1[CH3:11]Participants
5
Sources & evidence
- ORD record
- ord-e92161be909747929571b35ab406c6e3
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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