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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 940347Generated: October 27, 2026

Tetrahydrofuran → Trifluoro-methanesulfonic acid 3,5-dichloro-4-[cis-1-(4-fluoro-cyclohexyl)-2-oxo-pyrrolidin-3-ylmethyl]-phenyl ester

https://huagongshe.com/reaction/940347

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
ReactantLithium ionHCID 28486—
ReactantDiisopropylamideHCID 5062348—
Reactantcis-1-(4-Fluoro-cyclohexyl)-pyrrolidin-2-oneHCID 57878602—
ReactantTrifluoro-methanesulfonic acid 3,5-dichloro-4-methanesulfonyloxymethyl-phenyl esterHCID 86634570—
ProductTrifluoro-methanesulfonic acid 3,5-dichloro-4-[cis-1-(4-fluoro-cyclohexyl)-2-oxo-pyrrolidin-3-ylmethyl]-phenyl esterHCID 57878601—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-28945fcc1c354e7aa543c07b226ed785
Source noteValidation data from https://doi.org/10.1039/C8SC04228D