反应详情

温度

100 °C

A solution of hydrochloric acid in ethanol was added to a solution of tert-butyl [4-(methanesulfonylamino)butyl]carbamate (18.9 g, 71.1 mmol) in ethanol (100 mL), and the reaction was heated at 100° C. for two hours. The solvent was removed under reduced pressure. A mixture of dichloromethane:hexanes was added to the resulting oil and removed under reduced pressure; this process was repeated several times. The residue was dried for three days under vacuum to provide 14.3 g of N-(4-aminobutyl)methanesulfonamide hydrochloride as a tan solid.

1. customThe solvent was removed under reduced pressure
2. additionA mixture of dichloromethane
3. additionhexanes was added to the resulting oil
4. customremoved under reduced pressure
5. customThe residue was dried for three days under vacuum