Dichloromethane → 5-Dimethylamino-1-methyl-3-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one

HRID 941341Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([n:14]2[c:15](=[O:27])[n:16]([CH3:26])[c:17]3[c:18]2[n:19][c:20]([N:23]([CH3:24])[CH3:25])[cH:21][cH:22]3)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:35][CH2:36][Cl:37].[F:28][C:29]([F:30])([F:31])[C:32]([OH:33])=[O:34]>>[NH:8]1[CH2:9][CH2:10][CH:11]([n:14]2[c:15](=[O:27])[n:16]([CH3:26])[c:17]3[c:18]2[n:19][c:20]([N:23]([CH3:24])[CH3:25])[cH:21][cH:22]3)[CH2:12][CH2:13]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 691585984-(5-Dimethylamino-1-methyl-2-oxo-1,2-dihydro-imidazo[4,5-b]pyridin-3-yl)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 222938675-Dimethylamino-1-methyl-3-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one

Sources & evidence

ORD record: ord-9148ff8d2993456096e65a23b888d390
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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