Dichloromethane → 3-(Piperidin-4-yl)benzonitrile

HRID 941514Notes

Reaction equation

[C:1](#[N:2])[c:3]1[cH:4][c:5]([CH:9]2[CH2:10][CH2:11][N:12]([C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:13][CH2:14]2)[cH:6][cH:7][cH:8]1.[Cl:29][CH2:30][Cl:31].[F:22][C:23]([F:24])([F:25])[C:26]([OH:27])=[O:28]>>[C:1](#[N:2])[c:3]1[cH:4][c:5]([CH:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[cH:6][cH:7][cH:8]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 59261051Tert-butyl 4-(3-cyanophenyl)piperidine-1-carboxylate

Product 1

HCID 214481663-(Piperidin-4-yl)benzonitrile

Sources & evidence

ORD record: ord-e0f1d29ae43b4655a8f1993eabb6b69b
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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