Dichloromethane → 2-Phenyl-3-oxo-piperidine

HRID 941531Notes

Reaction equation

HRID 941531 reaction equation
[C:8]([O:9][C:10](=[O:11])[N:15]1[CH:16]([c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[C:17](=[O:21])[CH2:18][CH2:19][CH2:20]1)([CH3:12])([CH3:13])[CH3:14].[CH2:28]([Cl:29])[Cl:30].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[NH:15]1[CH:16]([c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[C:17](=[O:21])[CH2:18][CH2:19][CH2:20]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 11414684tert-Butyl 3-oxo-2-phenylpiperidine-1-carboxylate

Product 1

HCID 115792092-Phenyl-3-oxo-piperidine

Sources & evidence

ORD record
ord-b52cf783029748329261c2e04bb4dfae
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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