Toluene → Benzyl 2-[[4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]imidazol-1-yl]methyl]piperidine-1-carboxylate

HRID 941731Notes

Reaction equation

HRID 941731 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[n:15]([CH2:30][CH:31]3[N:32]([CH2:37][c:38]4[cH:39][cH:40][cH:41][cH:42][cH:43]4)[CH2:33][CH2:34][CH2:35][CH2:36]3)[cH:16][c:17](-[c:19]3[cH:20][c:21]([C:26]([F:27])([F:28])[F:29])[c:22]([F:25])[cH:23][cH:24]3)[n:18]2)[CH2:12][CH2:13]1.[CH3:55][c:56]1[cH:57][cH:58][cH:59][cH:60][cH:61]1.[Cl:44][C:45](=[O:46])[O:47][CH2:48][c:49]1[cH:50][cH:51][cH:52][cH:53][cH:54]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[n:15]([CH2:30][CH:31]3[N:32]([C:45](=[O:46])[O:47][CH2:48][c:49]4[cH:50][cH:51][cH:52][cH:53][cH:54]4)[CH2:33][CH2:34][CH2:35][CH2:36]3)[cH:16][c:17](-[c:19]3[cH:20][c:21]([C:26]([F:27])([F:28])[F:29])[c:22]([F:25])[cH:23][cH:24]3)[n:18]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 1140TolueneHCID 10387Benzyl chloroformateHCID 593224464-(1-((1-Benzylpiperidin-2-yl)methyl)-4-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 59322405Benzyl 2-[[4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]imidazol-1-yl]methyl]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-982e72b481e14daeb3a40d1d5ccbbc11
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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