Acetate → tert-Butyl 4-oxo-3-(1-oxoprop-1-yl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

HRID 941833Notes

Reaction equation

HRID 941833 reaction equation
[C:29]([O-:30])(=[O:31])[CH3:32].[C:34]([O-:35])(=[O:36])[CH3:37].[C:38]([O-:39])(=[O:40])[CH3:41].[CH3:1][O:2][C:3]1([C:16]([C:17]([C:18]([CH2:19][CH3:20])=[O:21])=[N+:22]=[N-:23])=[O:24])[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:7][CH2:8]1.[Cl:25][CH2:26][Cl:27].[ClH:28].[Rh+3:33]>>[CH2:1]1[O:2][C:3]2([CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:7][CH2:8]2)[C:16](=[O:24])[CH:17]1[C:18]([CH2:19][CH3:20])=[O:21]

Participants

6

Reactant 5

HCID 175Acetate3×HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 167511Rhodium(3+)HCID 73857865tert-Butyl 4-methoxy-4-(2-diazo-1,3-dioxopent-1-yl)piperidine-1-carboxylate

Product 1

HCID 21983892tert-Butyl 4-oxo-3-(1-oxoprop-1-yl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Sources & evidence

ORD record
ord-4cc9a8982287437ba73e8e3b36ffabbe
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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