2-Hydroxy-4-iodobenzoic acid → 4-[3-(3-Tert-butyl-5-chloro-4-dimethylaminophenyl)-3-hydroxyprop-1-ynyl]-2-hydroxybenzoic acid
Reaction equation
[C:12]([CH3:13])([CH3:14])([CH3:15])[c:16]1[cH:17][c:18]([CH:26]([C:27]#[CH:28])[OH:29])[cH:19][c:20]([Cl:25])[c:21]1[N:22]([CH3:23])[CH3:24].[Cu:30]([I:31])[I:32].[OH:1][c:2]1[c:3]([C:4](=[O:5])[OH:6])[cH:7][cH:8][c:9]([I:11])[cH:10]1>>[OH:1][c:2]1[c:3]([C:4](=[O:5])[OH:6])[cH:7][cH:8][c:9]([C:28]#[C:27][CH:26]([c:18]2[cH:17][c:16]([C:12]([CH3:13])([CH3:14])[CH3:15])[c:21]([N:22]([CH3:23])[CH3:24])[c:20]([Cl:25])[cH:19]2)[OH:29])[cH:10]1Participants
4
Sources & evidence
- ORD record
- ord-ab3348b4838747a7beb7b4c37360cfcb
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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