Toluene → N4-{[3-(4-fluorophenyl)isoxazol-5-yl]methyl}[1,5]naphthyridine-3,4-diamine
Reaction equation
[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[CH:35]([OH:36])([CH3:37])[CH3:38].[F:8][c:9]1[cH:10][cH:11][c:12](-[c:15]2[n:16][o:17][c:18]([CH2:20][NH:21][c:22]3[c:23]([N+:32]([O-:33])=[O:34])[cH:24][n:25][c:26]4[cH:27][cH:28][cH:29][n:30][c:31]34)[cH:19]2)[cH:13][cH:14]1>>[F:8][c:9]1[cH:10][cH:11][c:12](-[c:15]2[n:16][o:17][c:18]([CH2:20][NH:21][c:22]3[c:23]([NH2:32])[cH:24][n:25][c:26]4[cH:27][cH:28][cH:29][n:30][c:31]34)[cH:19]2)[cH:13][cH:14]1Participants
4
Sources & evidence
- ORD record
- ord-e453e972affa4b828f72f8088c9df4cd
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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