Hydrogen Peroxide → 5-Chloro-6-((3,3-difluorocyclobutyl)methoxy)pyridin-3-OL

HRID 942448Notes

Reaction equation

HRID 942448 reaction equation
[CH3:31][OH:32].[Cl:1][c:2]1[c:3]([O:17][CH2:18][CH:19]2[CH2:20][C:21]([F:23])([F:24])[CH2:22]2)[n:4][cH:5][c:6]([B:8]2[O:9][C:10]([CH3:11])([CH3:12])[C:13]([CH3:14])([CH3:15])[O:16]2)[cH:7]1.[OH:25][OH:26].[S:27]([O-:28])([O-:29])=[S:30]>>[Cl:1][c:2]1[c:3]([O:17][CH2:18][CH:19]2[CH2:20][C:21]([F:23])([F:24])[CH2:22]2)[n:4][cH:5][c:6]([OH:29])[cH:7]1

Participants

5

Reactant 4

HCID 784Hydrogen PeroxideHCID 887MethanolHCID 9548651Thiosulfite(2-)HCID 580424833-Chloro-2-((3,3-difluorocyclobutyl)methoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)pyridine

Product 1

HCID 580423895-Chloro-6-((3,3-difluorocyclobutyl)methoxy)pyridin-3-OL

Sources & evidence

ORD record
ord-b2b7654b495a4496883b7608bc0912cb
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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