Chloride → 1'-Benzyl-6-chloro-3,4-dihydrospiro[chromene-2,4'-piperidine]

HRID 942491Notes

Reaction equation

HRID 942491 reaction equation
[Al+3:2].[CH2:5]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[N:12]1[CH2:13][CH2:14][C:15]2([O:16][c:17]3[cH:18][cH:19][c:20]([Cl:26])[cH:21][c:22]3[C:23](=[O:25])[CH2:24]2)[CH2:27][CH2:28]1.[Cl-:1].[Cl-:3].[Cl-:4].[Cl:29][CH2:30][Cl:31]>>[CH2:5]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[N:12]1[CH2:13][CH2:14][C:15]2([O:16][c:17]3[cH:18][cH:19][c:20]([Cl:26])[cH:21][c:22]3[CH2:23][CH2:24]2)[CH2:27][CH2:28]1

Participants

5

Reactant 4

HCID 312Chloride3×HCID 6344DichloromethaneHCID 104727Aluminum CationHCID 128879541'-Benzyl-6-chlorospiro[chroman-2,4'-piperidin]-4-one

Product 1

HCID 598336421'-Benzyl-6-chloro-3,4-dihydrospiro[chromene-2,4'-piperidine]

Sources & evidence

ORD record
ord-bec71d9ced0c404d8ae10959ee22b403
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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