Dichloromethane → N-(4-(7-methoxy-1,5-naphthyridin-4-ylthio)phenyl)-4-(1,2,3,6-tetrahydropyridin-4-yl)phthalazin-1-amine

HRID 942555Notes

Reaction equation

[CH3:1][O:2][c:3]1[cH:4][n:5][c:6]2[c:7]([S:13][c:14]3[cH:15][cH:16][c:17]([NH:20][c:21]4[n:22][n:23][c:24]([C:31]5=[CH:32][CH2:33][N:34]([C:37]([O:38][C:39]([CH3:40])([CH3:41])[CH3:42])=[O:43])[CH2:35][CH2:36]5)[c:25]5[cH:26][cH:27][cH:28][cH:29][c:30]45)[cH:18][cH:19]3)[cH:8][cH:9][n:10][c:11]2[cH:12]1.[Cl:51][CH2:52][Cl:53].[F:44][C:45]([F:46])([F:47])[C:48]([OH:49])=[O:50]>>[CH3:1][O:2][c:3]1[cH:4][n:5][c:6]2[c:7]([S:13][c:14]3[cH:15][cH:16][c:17]([NH:20][c:21]4[n:22][n:23][c:24]([C:31]5=[CH:32][CH2:33][NH:34][CH2:35][CH2:36]5)[c:25]5[cH:26][cH:27][cH:28][cH:29][c:30]45)[cH:18][cH:19]3)[cH:8][cH:9][n:10][c:11]2[cH:12]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 67317430tert-butyl 4-(4-(4-(7-methoxy-1,5-naphthyridin-4-ylthio)phenylamino)phthalazin-1-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Product 1

HCID 59427364N-(4-(7-methoxy-1,5-naphthyridin-4-ylthio)phenyl)-4-(1,2,3,6-tetrahydropyridin-4-yl)phthalazin-1-amine

Sources & evidence

ORD record: ord-2f952a47d06d42959994d2478435f27d
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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