Acetonitrile → 5-Benzyloxy-2-fluoromethyl-pyran-4-one

HRID 942753Notes

Reaction equation

HRID 942753 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10](=[O:21])[cH:11][c:12]([CH2:15][O:16][S:17]([CH3:18])(=[O:19])=[O:20])[o:13][cH:14]1.[CH3:23][CH2:24][CH2:25][CH2:26][N+:27]([CH2:28][CH2:29][CH2:30][CH3:31])([CH2:32][CH2:33][CH2:34][CH3:35])[CH2:36][CH2:37][CH2:38][CH3:39].[CH3:40][C:41]#[N:42].[CH3:43][CH2:44][O:45][C:46](=[O:47])[CH3:48].[F-:22]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10](=[O:21])[cH:11][c:12]([CH2:15][F:22])[o:13][cH:14]1

Participants

6

Reactant 5

HCID 6342AcetonitrileHCID 8857Ethyl AcetateHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 84562570methanesulfonic acid 5-benzyloxy-4-oxo-4H-pyran-2-ylmethyl ester

Product 1

HCID 866235005-Benzyloxy-2-fluoromethyl-pyran-4-one

Sources & evidence

ORD record
ord-85a65454ed0143c5944793e2a2444b3b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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