Dichloromethane → 4-(2-tert-butyl-4-nitro-1H-pyrrole-5-carbonyl)-3,3-dimethylpiperazin-2-one

HRID 942901Notes

Reaction equation

HRID 942901 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([N+:13](=[O:14])[O-:15])[c:8]([C:10](=[O:11])[OH:12])[nH:9]1.[CH3:16][C:17]1([CH3:24])[C:18](=[O:23])[NH:19][CH2:20][CH2:21][NH:22]1.[CH:25]([N:26]([CH2:27][CH3:28])[CH:29]([CH3:30])[CH3:31])([CH3:32])[CH3:33].[Cl:34][CH2:35][Cl:36]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([N+:13](=[O:14])[O-:15])[c:8]([C:10](=[O:12])[N:22]2[C:17]([CH3:16])([CH3:24])[C:18](=[O:23])[NH:19][CH2:20][CH2:21]2)[nH:9]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 81531DiisopropylethylamineHCID 2111572-Piperazinone, 3,3-dimethyl-HCID 183223915-tert-butyl-3-nitro-1H-pyrrole-2-carboxylic acid

Product 1

HCID 586792724-(2-tert-butyl-4-nitro-1H-pyrrole-5-carbonyl)-3,3-dimethylpiperazin-2-one

Sources & evidence

ORD record
ord-3f85ff3b530a420da17a716ab4601fbe
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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